Antidepressant-like effect of ethanol extract of Blighia unijugata Bak. (Sapindaceae) leaves in acute and chronic models of depression in mice.

Blighia unijugata (Sapindaceae) is an indigenous tree belonging to the tropical forests of West Africa. It is called "Ako Isin" by the Yoruba people of Southern-Western part of Nigeria, where it is among plants used traditionally in the management of depressive psychosis. The aim of this present study was to evaluate the anti-depressant activity of ethanol extract of Blighia unijugata leaves in-vivo using acute and chronic experimental models of depression. The antidepressant activity of ethanol extract of B. unijugata leaves was investigated using acute and chronic unpredictable mild stress. Depression tests used included forced swimming, tail suspension, yohimbine induced lethality and reserpine induced depression tests. Oxidative stress markers were also assessed in the brain homogenates after chronic unpredictable mild stress. The acute toxicity studied using oral route of administration was 1414 mg/kg. The results showed that, B. unijugata produced significant reduction in immobility time in forced swimming and tail suspension tests without stimulating in locomotor activity in open field test. It was also found that B. unijugata significantly reversed diarrhea, ptosis and hypothermia in reserpine model of depression. 2.5 mg/kg B. unijugata potentiated yohimbine induced lethality in mice and also reduced the oxidative stress markers. The ethanol extract of B. unijugata leaves possessed antidepressant action, thus justifying its use in the management of mental illness.

Evaluation of Antidepressant-like Effect of Olax Subscorpioidea Oliv. (Olacaceae) Extract in Mice.

Olax subscorpioidea is a shrub or tree found in Nigeria, and other parts of Africa. It is indicated in the management of inflammatory disorder, mental illness, convulsion, pain, and cancer.Based on the folkloric use in the management of mental illness, antidepressant activity of Olax subscorpioidea (6.25-50 mg/kg, i. p.) was investigated using forced swimming, tail suspension, yohimbine induced lethality and reserpine induced depression tests.The results showed that, Olax subscorpioidea produced significant dose dependent reduction in immobility time in forced swimming [F (5, 24) = 17.22, p < 0.0001] and tail suspension [F (5, 24) = 14.94, p < 0.0001] tests without causing changes in locomotor activity in open field test. It was also found that Olax subscorpioidea significantly reduced diarrhea in reserpine model of depression [F (5, 24) = 10, p < 0.0001]. None of the doses potentiated yohimbine induced lethality in mice. In conclusion Olax subscorpioidea possessed antidepressant action, thus justifying its use in the management of mental illness.